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Reglan is also used to treat gastroparesisslow stomach emptyingin people with diabeteswhich can cause heartburn and stomach discomfort after meals.

A few cases of neutropenialeukopeniaor agranulocytosisgenerally without clear-cut relationship to metoclopramideMethemoglobinemiain adults and especially with overdosage in neonatessee OVERDOSESulfhemoglobinemia in adults.

The management of NMS should include 1immediate discontinuation of metoclopramide and other drugs not essential to concurrent therapy2intensive symptomatic treatment and medical monitoringand 3treatment of any concomitant serious medical problems for which specific treatments are availableBromocriptine and dantrolene sodium have been used in treatment of NMSbut their effectiveness have not been establishedsee ADVERSE REACTIONS

There are insufficient reliable data to conclude whether the pharmacokinetics of metoclopramide in adults and the pediatric population are similarAlthough there are insufficient data to support the efficacy of metoclopramide in pediatric patients with symptomatic gastroesophageal refluxGERor cancer chemotherapy-related nausea and vomitingits pharmacokinetics have been studied in these patient populations.

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